HomeProceduresPRP皮膚再生療法

PRP皮膚再生療法: Downtime

Mild Category: Skin Boosters & Collagen Stimulators Last updated: 2026-07-13
PRP skin rejuvenation is a treatment in which your own blood is drawn and spun in a centrifuge to extract the platelet-rich component (platelet-rich plasma, or PRP), which is then injected into areas where fine lines or loss of firmness are a concern. The growth factors contained in platelets are said to work on the skin's natural repair processes, aiming to improve fine crepey lines under the eyes and the skin's firmness and glow. Results are generally said to appear gradually over several weeks to several months rather than immediately after injection, and how they appear and how long they last vary from person to person. Note that PRP therapy falls under Japan's Act on the Safety of Regenerative Medicine, and medical institutions providing it are required to file a regenerative medicine provision plan with the national government (the Ministry of Health, Labour and Welfare). As for downtime, swelling and redness at the injection sites typically last 2–3 days, and if bruising occurs, about 1–2 weeks is a common guideline. This page outlines the typical course from treatment day to the final result, along with everyday precautions. Actual recovery varies from person to person, so please make your final decision after being examined by a physician.
Downtime2–3 days
PainMild
MakeupFrom the next da…
Work / social lifeOften said to be…

Downtime at a glance

Swelling and redness at the injection sites typically last 2–3 days, and bruising, if it occurs, about 1–2 weeks. The under-eye area is prone to swelling and puffiness, so allowing extra time before important events is reassuring.

Typical downtime is 2–3 days (swelling and redness); if bruising occurs, it often fades within about 1–2 weeks, and most people feel comfortable being seen in public after Often said to be possible from the next day (for areas where swelling shows easily, such as under the eyes, allowing 2–3 days is safer). How much swelling or bruising appears varies from person to person, depending on constitution and the extent of treatment.

Recovery timeline: treatment day to final result

Treatment day

After your blood is drawn, the centrifuged PRP is injected. Swelling, redness, and needle marks tend to appear at the injection sites, and under the eyes you may notice a puffy, swollen feeling. On the day itself, avoid rubbing the treated area, and it is safest to skip alcohol, strenuous exercise, long baths, saunas, and other activities that strongly boost circulation. If you cool the area, follow your clinic's instructions.

Next day

This is when swelling and puffiness tend to be most noticeable. If bruising develops, it may appear as a purplish mark around this time. Makeup is generally considered fine from the next day as long as the needle marks have settled, and many people are said to manage desk work as usual.

Day 3

Swelling and redness begin to settle around this time. In thin-skinned areas such as under the eyes, puffiness or slight fullness may continue a little longer. Bruising can be covered with makeup while you watch how it progresses.

1 week later

Swelling is often barely noticeable by this point. Any bruising typically takes on a yellowish tinge and fades to a level that concealer can hide. Changes in the skin are usually not yet noticeable at this stage — from here, you wait for gradual improvement.

2 weeks later

Downtime symptoms have generally settled for most people by this time. It is a good point to check for any remaining lumps or unevenness yourself, and to contact the medical institution where you had the procedure if anything concerns you.

1 month later

Some people are said to begin noticing changes in skin firmness and texture around this time. The degree and timing of change vary widely from person to person, and one session alone may not produce a noticeable difference. If you are planning multiple sessions, discuss the timing of the next one with your doctor.

2–3 months later

This is when changes associated with the production of collagen and other components are said to become fully apparent. It is a good time to evaluate the result and consider additional sessions or combinations with other treatments. Because the degree and duration of results vary from person to person, discuss next steps with your doctor.

Bars show approximate swelling levels (individual results vary).

Common symptoms

SymptomLikelihoodWhen it appearsHow long it lastsNotes
Swelling and puffinessHighImmediately after treatment2–3 daysCaused by the volume of injected fluid and the needle's irritation, this tends to be more noticeable in thin-skinned areas such as under the eyes. It is generally said to settle within a few days.
Redness and needle marksHighImmediately after treatment1–3 daysTemporary redness and small needle marks may appear at the injection points, but within a few days they can often be covered with makeup.
BruisingMediumSame day to the next day1–2 weeksBruising can occur if the needle touches a small blood vessel. It tends to appear more easily in thin-skinned areas such as under the eyes and around the mouth.
Dull ache or tenderness when pressedMediumImmediately after treatment to a few daysA few daysTenderness or discomfort at the injection sites is generally said to ease within a few days. If strong pain persists, consult your doctor.
Itching or warmthLowSame day to a few daysA few daysThese are considered temporary symptoms that accompany the tissue's repair response. If intense itching or spreading redness develops, seek medical attention promptly.
Lumps or unevennessLowA few days to a few weeks laterSeveral weeks or longer (depending on severity)You may feel temporary firmness or unevenness at the injection sites. Most cases are said to smooth out over time, but if it lingers or a bump is pronounced, consult the doctor who performed the procedure.

When can I do what? (Daily-life restrictions)

ActivityTypically OK fromKey point
MakeupFrom the next dayIt is common to avoid makeup on the day of treatment to prevent infection through the needle marks. From the next day onward, avoid rubbing the injection points firmly.
Washing your faceFrom the same day (gently, without rubbing)It is safer to avoid firm massage or pressure on the injection sites for a few days to a week.
ShowerUsually considered fine from the same dayA lukewarm shower is generally considered to be no problem.
Bathing (soaking in the tub)From the next day to 2 days later as a guideA long soak on the day of treatment boosts circulation and can make swelling and bruising more pronounced, so it is safest to avoid it.
AlcoholFrom 2–3 days later as a guideIncreased circulation can prolong swelling and bruising, so it is common to abstain at least on the day of treatment.
ExerciseLight exercise from the next day / strenuous exercise from 2–3 days later as a guideIncreased blood flow can make swelling and bruising more noticeable.
Sauna and hot-stone bathsFrom about 1 week later as a guideHigh heat boosts circulation and can cause swelling and bruising to flare up again, so it is safest to hold off for a while.
Massage or facial treatments on the treated areaFrom about 1–2 weeks later as a guideFirmly kneading the injection sites can lead to swelling or unevenness, so it is common to wait until things have settled.
Sleeping face-down / pressure on the treated areaFrom 2–3 days later as a guideIf the injections were under the eyes or in the cheeks, pressure during sleep can make puffiness worse. Raising your pillow slightly is said to help swelling subside.
Taking fever reducers (anti-inflammatory painkillers) on your own judgmentFollow your doctor's instructionsBecause PRP works through the body's natural repair response, some clinics give specific guidance on medications that strongly suppress inflammation. Be sure to tell your doctor in advance about any medications you are taking.
Can you hide it? Concealment difficulty ●●○○○ / Swelling and bruising on the cheeks or around the mouth are in areas that a mask covers easily. Under-eye swelling and dusky-looking bruising cannot be hidden by a mask, so from the next day onward, combining concealer or foundation with plain-lens or thick-framed glasses can make them less noticeable. For purplish bruises, applying a yellow-to-orange color corrector or concealer underneath is said to neutralize the color and make coverage easier. How well it can be concealed varies from person to person.

Pain and anesthesia

The typical pain level is Mild. A topical numbing cream and cooling are commonly used together. If you are worried about pain, ask your doctor about anesthesia options in advance. There is the pain of the blood draw, plus a brief pricking sensation during injection and a feeling of pressure as the fluid goes in. Thin-skinned areas such as under the eyes can feel somewhat more sensitive, but many clinics use a topical numbing cream, and most people are said to find the discomfort tolerable. Sensitivity varies from person to person.

Tips for a smoother recovery

Risks and side effects (the honest version)

If a symptom lingers or gets worse, do not try to judge it yourself — contact the medical institution where you had the procedure.

Spacing and combining with other procedures

If you have a wedding, photo shoot, or other big event, having the treatment at least 2–4 weeks beforehand allows time for swelling and bruising to settle. If you want the skin-quality changes to be ready in time for the event, keep in mind that results appear over several weeks to several months, and discuss a plan starting 2–3 months or more in advance with your doctor. If having multiple sessions, a common plan is said to be 2–3 sessions spaced about 1–3 months apart as a general guide. Because treatment proceeds while watching how your skin responds, follow your doctor's judgment on the number and spacing of sessions.

Combined procedureTimingWait timeReason
Botox InjectionSame day OKSometimes combined on the same dayAn injection that works on the skin's repair processes and an injection into the expression muscles have different goals, and as long as the areas do not overlap, they can often be done on the same day. Because swelling and bruising can overlap, your doctor will decide the order and whether to combine them.
Hyaluronic Acid FillerWait requiredAbout 1–2 weeks as a guide (same day may be possible for separate areas)Injecting into the same area on the same day can cause swelling and bruising to overlap, making it hard to tell which treatment is behind what you see. If you plan to divide the roles — hyaluronic acid for volume, PRP for skin quality — discuss the order and spacing with your doctor.
Pigment Spot Laser / Laser ToningWait requiredAbout 1–2 weeks as a guideApplying laser while the injection sites are still swollen or red stacks irritation on irritation and makes progress harder to assess, so it is considered safer to wait until the downtime has settled.
Needle RF (Microneedle Radiofrequency)Wait requiredAbout 2 weeks as a guideIf the downtime from fine-needle irritation and heat overlaps, swelling and redness can become more pronounced. Some clinics offer the two as a combination, but follow your doctor's plan on whether to have them in the same period.
HIFU (High-Intensity Focused Ultrasound)Wait requiredAbout 2 weeks as a guideIf heat-related swelling and puffiness overlap with the recovery of the injection sites, the results become hard to evaluate, so having them one after another with an interval is generally recommended. The best order depends on your goals, so discuss it with your doctor.

Who it may suit / who should be cautious

May suit you

  • Those concerned about fine crepey lines or small wrinkles under the eyes or around the mouth
  • Those who feel their skin has lost firmness, glow, or smoothness of texture
  • Those hesitant about injecting synthetic materials such as hyaluronic acid who prefer a treatment derived from their own blood
  • Those who want a gradual improvement in skin quality over time
  • Those concerned about uneven skin texture such as acne scars (suitability must be confirmed at an examination)

Consider carefully

  • Those with blood disorders or platelet abnormalities
  • Those taking anticoagulant or antiplatelet medication whom a doctor judges unsuitable
  • Those with an infection or inflammation in the treatment area
  • Those who are pregnant or breastfeeding
  • Those with serious medical conditions, such as ongoing cancer treatment, whom a doctor judges unsuitable
  • Those seeking a dramatic change immediately after treatment (results are gradual and vary widely from person to person)

Frequently asked questions

Does PRP skin rejuvenation hurt?
There is the pain of the blood draw, plus a brief pricking sensation and a feeling of pressure during injection. Many clinics use a topical numbing cream, and most people are said to find it tolerable, though thin-skinned areas such as under the eyes can feel somewhat more sensitive. Sensitivity varies from person to person, so if you are worried about pain, ask your doctor about anesthesia options in advance.
How long is the downtime, and will I need time off work?
Swelling and redness typically last 2–3 days, and bruising, if it occurs, about 1–2 weeks. Desk work is often said to be possible from the next day, but because under-eye swelling shows easily, allowing 2–3 days is safer if your work puts you in front of people. Recovery varies from person to person.
When will I start to see results?
Rather than an immediate change after injection, results are said to appear gradually over several weeks to several months as the growth factors in platelets stimulate the production of collagen and other components. Some people begin to notice a change around the 1-month mark, while others only see a difference after multiple sessions — individual variation is considerable. Ask about the likely outlook at your consultation.
If it uses my own blood, does that mean there are no risks?
Because it is derived from your own blood, allergic reactions are considered unlikely, but that does not mean there are no risks. Besides swelling and bruising, infection from the injections and lumps or unevenness are possible. In particular, methods that add growth factors (such as bFGF) are not an approved use in Japan, and there are reports of excessive fullness, so we recommend confirming in advance whether any additives are used.
What is the "regenerative medicine filing," and should I check it before having the procedure?
PRP therapy falls under Japan's Act on the Safety of Regenerative Medicine. After review by a certified committee for regenerative medicine, providing medical institutions must file a regenerative medicine provision plan with the national government. Providing the treatment without this filing is not permitted, so it is reassuring to confirm at your consultation that the filing has been made. Filed provision plans can also be checked on the Ministry of Health, Labour and Welfare website.
How many sessions will I need?
Some people notice a change after a single session, but a course of multiple sessions (around 2–3) spaced about 1–3 months apart is often recommended. The number needed depends on your skin's condition and the change you are aiming for, and results vary from person to person. We recommend discussing a plan with your doctor in advance, including what the total cost will be.
How is it different from hyaluronic acid filler?
Hyaluronic acid filler creates volume right away with the product itself, whereas PRP is said to work on the skin's repair processes using components of your own blood, aiming for gradual change over several weeks to several months. Which suits you depends on whether you want an immediate effect or a slower improvement in skin quality over time, so discuss your goals with your doctor.
Does it help with dark circles under the eyes?
Changes may be expected for fine crepey lines under the eyes and dullness caused by reduced skin firmness, while dark circles caused by pigmentation, or mainly by sagging or puffiness, may be better suited to other treatments. Because the appropriate approach differs by the type of dark circles, we recommend deciding after a physician has examined you and identified the cause.
This article was written and is kept up to date by our editorial team, based on general knowledge in cosmetic surgery and aesthetic dermatology, the package inserts of the products and medical devices involved, and publicly available information from government agencies and medical societies. It is not an advertisement for any specific medical institution. Editorial policy
This article is for general informational purposes only and is not an advertisement for any specific medical institution. All figures are typical guidelines; results and recovery vary from person to person. Please see a physician before making any final decision. The information on this site is provided for general informational purposes only and is not a substitute for diagnosis, treatment, or medical advice. Final decisions about a procedure's suitability, risks, combinations, and intervals must always be made after being examined by a physician.